The Effect of Statins on Erectile Dysfunction: A Systematic Review and Meta‐Analysis

In detail, the association was statistically significant for all statins (adjusted ROR [aROR] = 2. )” Kostis also adds that the erectile function benefits associated with statin use was larger than the reported effect of lifestyle modification. Patients were asked to have sexual intercourse at least once per week, and they received medication for 12 weeks. At the end of 7 months, all the patients treated with simvastatin had evolved to mild ED, whereas in the placebo group, 83% had evolved to this degree of dysfunction, though this was not statistically significant. But there are plans to see if statins help impotent men who have healthy cholesterol levels. The benefits of statin therapy continue to grow in number and indications for their use seem to be ever-expanding. Why everyman with ed should have an external penile pump, it reduces the spontaneity of sex on a whim. The researchers extracted five-item International Inventory of Erectile Function (IIEF) scores.

A systematic review by Rizvi and colleagues ( 2020 ) showed that a substantial number of cases of ED associated withstatinusagehavebeenreportedtoregulatoryagencies. Multivariate analysis showed that ED was dependent on the treatment with statins (odds ratio, 1. )In another study, Dadkhah and colleagues ( 2020 ) evaluated 131 patients with ED not responding to sildenafil. People usually think she’s in her 20s. Food and sex: why plants are better than pills for sexual performance. The drug is often prescribed to help prevent stroke and heart attack but while statins are widely used as a cholesterol-reducing drug, it appears it also has versatile effects as to treat some other health conditions.

The term erectile dysfunction (ED), which replaced the emotive word ’impotence,’ is the inability to start and maintain an erection sufficient to achieve sexual intercourse.

You can learn more about salsalate as well as home remedies for joint pain and inflammation from “Graedons’ Guide to Alternatives for Arthritis. Destigmatizing female sexual dysfunction, this most common of female sexual dysfunctions involves a lack of sexual interest and willingness to be sexual. Diclofenac can be irritating to the digestive tract. Results of this experimental evaluation showed that atorvastatin improved sildenafil‐induced ICP: Additionally, in an experimental model of diabetes characterized by RhoA/ROCK overactivity, ED, and hypogonadism, it has been demonstrated that both testosterone and statin therapy restored electrically stimulated penile erection by down‐regulation of the RhoA/ROCK pathway; moreover, the effect of statin was obtained independently from the concomitant hypogonadal state ( Morelli et al, 2020 ). Statins are widely used to reduce cholesterol levels in an attempt to prevent cardiovascular diseases such as heart attacks. Of the 4,371 cases exposed to statins, the incidence of reported ED was 1. In this article, Dr. ⓒ 2020 TECHTIMES.

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However, a new study into the effects of cholesterol-lowering statins and blood-pressure lowering candesartan/HCTZ concludes that these medications do not negatively affect erectile function. The other 50 received no treatment. The study included 100 male patients (aged 40–70 years) with unique risk factor dyslipidemia (none of them was receiving lipid-lowering treatment) and erectile dysfunction. And in small to medium doses, none of these are at issue. This was a substudy of the Heart Outcomes Prevention Evaluation -- 3 (HOPE-3) randomized controlled trial, a 2x2 factorial randomized controlled trial testing candesartan/HCTZ versus placebo, rosuvastatin versus placebo, and the combination of these medications versus double placebo. Eleven randomized controlled trials in which ED was assessed were identified from the 186 results of a search conducted by the authors of Medline, Web of Knowledge, Cochrane Database, and ClinicalTrials. Treatments for erectile dysfunction go beyond a pill. Statins are unlikely to be prescribed for erectile dysfunction in men without cardiovascular risk factors; at least in the near future.

  • I am now on diclofenac and take Nexium (40 mg) for GERD.
  • A review in the Journal of Sexual Medicine found that people who took statins were less likely to experience symptoms of ED than those who did not.
  • The trials had an average of 53 patients per study, for a total of 647 patients.
  • 13, 95% CI = −1.
  • In the subgroup of patients receiving statins the IIEF score emerged a statistically significant increase after three months of treatment (16.)


Statins and male sexual health: 9% of cases, recovery occurred after withdrawal of statin, and rechallenge was positive in 5 cases. Goodrx, potassium supplementation lowers blood pressure and increases urinary kallikrein in essential hypertensives. Erectile dysfunction (ED), which can affect an estimated 18 to 30 million men in the United States, may be an early sign of endothelial dysfunction and poor vascular health. These studies suggest that the length of the treatment with simvastatin in our patients (6 months) should have been sufficient to detect changes in ED. The study was presented here today at the American College of Cardiology (ACC) 2020 Scientific Sessions and simultaneously published online in the Journal of Sexual Medicine[1]. In this study, a total of 50 potent men without hypercholesterolemia undergoing bilateral nerve‐sparing radical retropubic prostatectomy for clinically localized prostate cancer were prospectively randomized into 2 groups. Your library or institution may give you access to the complete full text for this document in ProQuest.

Research has clearly shown that men under 70 with pre-existing heart disease live longer if they take statins, but the advantages are less clear for women, those without disease and those over 70, she said. Youtube, with the emergence of new surgical technology such as Augmented Reality Assisted Surgery (ARAS) may further educate surgeons and warn of potential dangers along with simplifying the IPP operation (43). Natural cures and treatments for erectile dysfunction, this is not to say that I immediately separate patients from their antidepressants, but I inform them that this may be the cause of some or all of their symptoms. Presented at the American College of Cardiology’s 63rd Annual Scientific Session, this study reviewed 11 clinical trials investigating erectile function in recent years. 9 points in men who took statins - from 11.

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