Taking Statins Could Help Reduce Erectile Dysfunction, Study Suggests

Many health professionals no longer consider such drugs the first choice for treating high blood pressure. Statins are often prescribed to reduce LDL cholesterol levels. It was found that after liver transplantation, the proportion of sexually inactive men decreased significantly from 29% to 15%,but the proportion of men with ED remained unchanged. If you are trying to access this site from the United States and believe you have received this message in error, please reach out to [email protected]

Statins are used to control LDL Cholesterol in our bodies.

In the study presented at the American College of Cardiology conference, experts performed a meta-analysis on 11 previous randomised, controlled studies on erectile dysfunction and statins. We can see, however, that at the beginning of the study, 26% of the patients in both groups were classified as having mild ED and approximately 74% as having moderate-to-severe ED. Mechanisms of action of ED with statins have not been established but are believed to be due to statin-associated cholesterol suppression, resulting in insufficient levels for normal sexual hormone - primarily testosterone - production.

  • This research includes a meta-analysis adding up results from 11 randomised controlled trials that found a 24.
  • Erectile function was evaluated before and after all treatment regimens according to the IIEF‐5 questionnaire.
  • Data from randomised clinical trials showed no difference between simvastatin and placebo in the 4S study (37/1814 on simvastatin, 28/1803 on placebo), but erectile dysfunction was not reported in other randomised trials.
  • Peyronie’s disease High cholesterol is an associated risk factor for many of these conditions, and, therefore, it can also increase a person’s likelihood of having ED.
  • Except that while erection problems can be due to narrowed blood vessels, they are most often caused by stress, smoking or drinking too much alcohol.

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(5 to six months), and patient types. Evaluation of a multi-herb supplement for erectile dysfunction: a randomized double-blind, placebo-controlled study. In this dysfunction, there is a change in the NO metabolism in the penile corpus cavernosum, determining a state of arteriolar vasoconstriction, with a reduction of the blood inflow and consequent deficiency in penile erection. One case-control study looked at the prevalence of erectile dysfunction in 339 patients attending a lipid clinic compared with matched controls. Because statins can interfere with RhoA/Rho‐kinase signaling through the reduction of geranyl‐geranyl pyrophosphate required for RhoA activation, Morelli and colleagues ( 2020 ) investigated whether atorvastatin ameliorated diabetes‐related ED.

Other causes of ED

Strengths of the meta-analysis were that it included all published randomized trials about the topic, and the benefit remained after multiple sensitivity analyses. After statin assumption, the median IIEF‐5 score decreased significantly to 6. The trials had an average of 53 patients per study, for a total of 647 patients. Erectile dysfunction can be reversed without medication, advances in Therapy , 18 (4), 189–193. There are two main types of cholesterol: It may not have been the medication that’s the problem, but the clogged arteries the medicine was prescribed for.

  • Statins are commonly prescribed for people with ailments such as diabetes or heart disease, which can cause erectile dysfunction.
  • The absence of sexual activity was significantly associated with pretransplant sexual inactivity; age; cardiovascular diseases; and the use of statins, diuretics, anticoagulants, and antidiabetic drugs (Huyghe et al, 2020).

Is There A Link?

If your doctor prescribes statins to treat high cholesterol, it may not be the medication causing problems. Alprostadil injection and suppository for erectile dysfunction, pills for ED cost roughly to per dose. In this study, authors examined the intracavernous pressure: However, limitations were the inclusion of small studies with few participants and diverse statins, treatment duration (1. )

  • Questions also focused on patient perception of changes over time.
  • The study was presented here today at the American College of Cardiology (ACC) 2020 Scientific Sessions and simultaneously published online in the Journal of Sexual Medicine[1].
  • 7; finally, Rigi‐Scan measurements showed a significant increased average penile rigidity at the base and tip after treatment with atorvastatin ( Saltzman et al, 2020 ).

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The research included 100 men between the ages of 40 and 70 with erectile dysfunction and abnormal cholesterol. Many recent studies have attempted to link the growing incidence of erectile dysfunction with other causes, especially in patients suffering from cardiovascular diseases. A systematic review.

Do statins cause erectile dysfunction? One was a small, but randomised and double blind comparison of atorvastatin and placebo in 12 men with erectile dysfunction and who were taking sildenafil [6]. Systematic review of three English language randomized controlled trials published between 2020-2020. And patients do not have to take specific drugs for erectile dysfunction. Self-perceived effects of sandalwood, the inability to reach or maintain an erection can happen for a variety of reasons, such as an overconsumption of alcohol or fatigue. The main findings in the literature concern atorvastatin, in particular, because statins and sildenafil, a selective inhibitor of phosphodiesterase type 5 (PDE5i), can activate the nitric oxide (NO) cyclic guanosine monophosphate pathway.

I want to know if there is anything I can take for arthritis pain that will not give me stomach ulcers, raise my blood pressure or lead to a heart attack. Possible links to ED While ED isn’t a widely reported side effect of statins, researchers have explored the possibility. “But the important thing is that by improving cholesterol levels, patients were also benefiting from better erections.

Statins prevent your body from making new cholesterol and may help reduce the amount of plaque already built up on artery walls.


After 14 weeks of diabetes induction, basal and PDE5i‐elicited (intravenous mirodenafil, 1 mg/kg) erectile responses were assessed during cavernous nerve electrostimulation. (4%) cases of ED were found among the remaining 106 214 reports not exposed to statins. “Participants experienced a 43 per cent improvement in their erections, the effect is around half that of sildenafil [Viagra]. Though in most men testosterone metabolism in not affected by statin therapy, we have clear interference with testosterone biosynthesis in some of the affected men, and clear re-challenge evidence of the problem in others. “The increase in erectile function scores with statins was approximately one-third to one-half of what has been reported with drugs like Viagra, Cialis or Levitra,” said John B. Statins are unlikely to be prescribed for erectile dysfunction in men without cardiovascular risk factors; at least in the near future. The ACC’s Annual Scientific Session brings together cardiologists and cardiovascular specialists from around the world each year to share the newest discoveries in treatment and prevention.

There is growing evidence to suggest statins may also cut the risk of cancer and dementia. But the difference between statins was interesting. Statins can not only lower cholesterol, but can improve erections, according to research presented at the European Society of Cardiology Congress in Rome last week. I have normal sexual urges, but when we have the chance to make love, getting an erection is super difficult. The most frequent manifestations of reduced levels of testosterone may lead complaints about erectile dysfunction and reduced libido. During this time, average LDL-C levels dropped significantly from 138 to 91 mg/dL in the treated men but were virtually unchanged in control groups. Speaking at the European Society of Cardiology (ESC) Congress in Rome, lead researcher Alexios Samantzas from Elpis Hospital in Athens, Greece, said the results were “very significant”.

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Which means it could improve blood flow to your penis just as well, if not better, than a statin. Atorvastatin decreased mean LDL cholesterol by 43% and resulted in a significant improvement of sildenafil efficacy in the domain score of 7. How statins help improve erectile function is possibly similar to how Viagra, a popular prescription drug for erectile dysfunction, works. Statins are widely used to reduce cholesterol levels in an attempt to prevent cardiovascular diseases such as heart attacks.

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